Nicotine has very powerful effects on arteries throughout the body. Nicotine is a stimulant, it raises blood pressure, and is a vasoconstrictor, making it harder for the heart to pump through the constricted arteries. It causes the body to release its stores of fat and cholesterol into the blood. It has been speculated that nicotine [...]

 
A lethal dose of nicotine for rats is 50 mg/kg and for mice 3 mg/kg. Comparing with that, for adult humans 40–60 mg (0.5-1.0 mg/kg) can be a lethal dose. Nicotine therefore has a high toxicity in comparison to many other alkaloids such as cocaine, which has an LD50 of 95.1 mg/kg when administered to [...]

 
By binding to nicotinic acetylcholine receptors, nicotine increases the levels of several neurotransmitters – acting as a sort of “volume control”. It is thought that increased levels of dopamine in the reward circuits of the brain are responsible for the euphoria and relaxation and eventual addiction caused by nicotine consumption. Nicotine has a higher affinity [...]

 
Many of the cannabis users are not aware that the strength of the cannabis depends on the amount of THC (9-delta tetrahydrocannabinol) in the dose, which means that not all the doses are the same. It depends from who they take from. Some users mix the cannabis or hashish with tobacco before smoking, making it [...]